*************************************************************************** PHYSICIANS' DESK REFERENCE (R) Interaction Report for: MYHITLIST 961002 HOMEPAGE October 02, 1996 IMPORTANT NOTE: Includes drug-drug interactions cited in the PDR database. Check full prescribing information for inactive ingredients. Products Reviewed: Atarax Tablets & Syrup, Benadryl Capsules, Compazine Tablets, Dalmane Capsules, Valium Tablets, Diabinese Tablets, Lanoxin Tablets, Elavil Tablets, Feosol Capsules, Haldol Injection, Tablets and Concentrate, Mellaril Tablets, Inderal Tablets, Lasix Injection, Oral Solution and Tablets, Indocin Capsules, Feldene Capsules, Quinidex Extentabs, Reglan Tablets, TYLENOL PM, Extra Strength Pain Reliever/Sleep Aid Caplets, Geltabs, Gelcaps, Calan Tablets POTENTIAL DRUG INTERACTIONS Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P, may interact with: Compazine Tablets (Prochlorperazine), p. 2470, P. Result: The potentiating action of hydroxyzine must be considered when it is used concurrently. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: The potentiating action of hydroxyzine must be considered when it is used concurrently. Valium Tablets (Diazepam), p. 2183, P. Result: The potentiating action of hydroxyzine must be considered when it is used concurrently. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: The potentiating action of hydroxyzine must be considered when it is used concurrently. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: The potentiating action of hydroxyzine must be considered when it is used concurrently. Benadryl Capsules (Diphenhydramine Hydrochloride), p. 1898, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Additive effects. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Additive effects. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Additive effects. Valium Tablets (Diazepam), p. 2183, P. Result: Additive effects. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Additive effects. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Additive effects. Compazine Tablets (Prochlorperazine), p. 2470, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Benadryl Capsules (Diphenhydramine Hydrochloride), p. 1898, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Valium Tablets (Diazepam), p. 2183, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Co-administration results in increased plasma levels of both drugs. TYLENOL PM, Extra Strength Pain Reliever/Sleep Aid Caplets, Geltabs, Gelcaps (Acetaminophen, Diphenhydramine Hydrochloride), p. 1560, P. Result: Phenothiazines may intensify or prolong the action of other central nervous system depressants. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Additive effects. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Additive effects. Valium Tablets (Diazepam), p. 2183, P. Result: Additive effects. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Additive effects. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Additive effects. Valium Tablets (Diazepam), p. 2183, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Concurrent use not recommended. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Potentiated action of Valium; concurrent use not recommended. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Concurrent use not recommended. Elavil Tablets (Amitriptyline Hydrochloride), p. 2838, P. Result: Potentiated action of Valium. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Concurrent use not recommended. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Potentiated action of Valium; concurrent use not recommended. Diabinese Tablets (Chlorpropamide), p. 1935, P, may interact with: Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Co-administration may result in hyperglycemia leading to loss of control. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Co-administration may result in hyperglycemia leading to loss of control. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Potentiation of hypoglycemic action. Lasix Injection, Oral Solution and Tablets (Furosemide), p. 1240, P. Result: Co-administration may result in hyperglycemia leading to loss of control. Indocin Capsules (Indomethacin), p. 1680, P. Result: Potentiation of hypoglycemic action. Feldene Capsules (Piroxicam), p. 1965, P. Result: Potentiation of hypoglycemic action. Calan Tablets (Verapamil Hydrochloride), p. 2419, P. Result: Co-administration may result in hyperglycemia leading to loss of control. Lanoxin Tablets (Digoxin), p. 1128, P, may interact with: Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Additive effects on AV node conduction. Lasix Injection, Oral Solution and Tablets (Furosemide), p. 1240, P. Result: Diuretic-induced hypokalemia sensitizes the myocardium to digitalis resulting in possible digitalis toxicity. Indocin Capsules (Indomethacin), p. 1680, P. Result: Causes a rise in serum digoxin concentration, with the implication that digitalis intoxication may result. Quinidex Extentabs (Quinidine Sulfate), p. 2067, P. Result: Causes a rise in serum digoxin concentration, with the implication that digitalis intoxication may result. Reglan Tablets (Metoclopramide Hydrochloride), p. 2068, P. Result: Reduces intestinal digoxin absorption, resulting in unexpectedly low serum concentration. Calan Tablets (Verapamil Hydrochloride), p. 2419, P. Result: Causes a rise in serum digoxin concentration, with the implication that digitalis intoxication may result. Elavil Tablets (Amitriptyline Hydrochloride), p. 2838, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Amitriptyline may enhance the response to CNS depressants. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Concurrent use with drugs that are substrate for cytochrome P450IID6 may make normal metabolizer resemble poor metabolizer leading to higher than expected plasma concentrations of TCA with resultant toxicity; concurrent use with neuroleptics may result in hyperpyrexia, particularly in hot weather. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Amitriptyline may enhance the response to CNS depressants. Valium Tablets (Diazepam), p. 2183, P. Result: Amitriptyline may enhance the response to CNS depressants. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Concurrent use with neuroleptics may result in hyperpyrexia, particularly in hot weather. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Concurrent use with drugs that are substrate for cytochrome P450IID6 may make normal metabolizer resemble poor metabolizer leading to higher than expected plasma concentrations of TCA with resultant toxicity; concurrent use with neuroleptics may result in hyperpyrexia, particularly in hot weather. Quinidex Extentabs (Quinidine Sulfate), p. 2067, P. Result: Concurrent use with drugs that inhibit cytochrome P450IID6 may make normal metabolizer resemble poor metabolizer leading to higher than expected plasma concentrations of TCA with resultant toxicity. Feosol Capsules (Ferrous Sulfate), p. 2456, P. The labeling of this product lists no interactions with the other products entered. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. The labeling of this product lists no interactions with the other products entered. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Potentiation of central nervous system depressants. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Potentiation of central nervous system depressants. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Potentiation of central nervous system depressants. Valium Tablets (Diazepam), p. 2183, P. Result: Potentiation of central nervous system depressants. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Potentiation of central nervous system depressants. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Concurrent administration produces increases in plasma levels of thioridazine. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P, may interact with: Diabinese Tablets (Chlorpropamide), p. 1935, P. Result: Delay in the recovery of blood glucose to normal levels following insulin-induced hypoglycemia. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Hypotension and cardiac arrest have been reported with the concomitant use of propranolol and haloperidol. Indocin Capsules (Indomethacin), p. 1680, P. Result: Blunts antihypertensive effect of beta blocker. Feldene Capsules (Piroxicam), p. 1965, P. Result: Blunts antihypertensive effect of beta blocker. Calan Tablets (Verapamil Hydrochloride), p. 2419, P. Result: Both agents may depress myocardial contractility or AV conduction resulting in increased adverse reactions. Lasix Injection, Oral Solution and Tablets (Furosemide), p. 1240, P, may interact with: Lanoxin Tablets (Digoxin), p. 1128, P. Result: Concomitant therapy may exaggerate metabolic effects of hypokalemia, especially myocardial effects. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Added therapeutic effect. Indocin Capsules (Indomethacin), p. 1680, P. Result: Reduced natriuretic and antihypertensive effects of Lasix. Calan Tablets (Verapamil Hydrochloride), p. 2419, P. Result: Added therapeutic effect. Indocin Capsules (Indomethacin), p. 1680, P, may interact with: Lanoxin Tablets (Digoxin), p. 1128, P. Result: Increased serum digoxin concentration and prolonged half-life. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Blunting of antihypertensive effect of beta blockers. Lasix Injection, Oral Solution and Tablets (Furosemide), p. 1240, P. Result: Indomethacin reduces basal plasma renin activity (PRA) induced by furosemide; reduced diuretic, natriuretic, and antihypertensive effects of loop diuretics. Feldene Capsules (Piroxicam), p. 1965, P. Result: Concomitant use is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy. Feldene Capsules (Piroxicam), p. 1965, P, may interact with: Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Feldene might displace other highly protein bound drugs. Valium Tablets (Diazepam), p. 2183, P. Result: Feldene might displace other highly protein bound drugs. Elavil Tablets (Amitriptyline Hydrochloride), p. 2838, P. Result: Feldene might displace other highly protein bound drugs. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Feldene might displace other highly protein bound drugs. Indocin Capsules (Indomethacin), p. 1680, P. Result: Feldene might displace other highly protein bound drugs. Quinidex Extentabs (Quinidine Sulfate), p. 2067, P, may interact with: Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Additive cardiac depressive effects. Lanoxin Tablets (Digoxin), p. 1128, P. Result: Increased serum concentration of digoxin. Calan Tablets (Verapamil Hydrochloride), p. 2419, P. Result: Increased quinidine half-life and increase in serum quinidine level; potential hypotensive reactions. Reglan Tablets (Metoclopramide Hydrochloride), p. 2068, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Additive sedative effects. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Additive sedative effects. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Additive sedative effects. Valium Tablets (Diazepam), p. 2183, P. Result: Additive sedative effects. Lanoxin Tablets (Digoxin), p. 1128, P. Result: Diminished absorption from the stomach. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Additive sedative effects. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Additive sedative effects. TYLENOL PM, Extra Strength Pain Reliever/Sleep Aid Caplets, Geltabs, Gelcaps (Acetaminophen, Diphenhydramine Hydrochloride), p. 1560, P. Result: Increased rate and/or extent of absorption from the small bowel. TYLENOL PM, Extra Strength Pain Reliever/Sleep Aid Caplets, Geltabs, Gelcaps (Acetaminophen, Diphenhydramine Hydrochloride), p. 1560, P, may interact with: Atarax Tablets & Syrup (Hydroxyzine Hydrochloride), p. 2185, P. Result: Effect not specified. Compazine Tablets (Prochlorperazine), p. 2470, P. Result: Effect not specified. Dalmane Capsules (Flurazepam Hydrochloride), p. 2173, P. Result: Effect not specified. Valium Tablets (Diazepam), p. 2183, P. Result: Effect not specified. Haldol Injection, Tablets and Concentrate (Haloperidol), p. 1575, P. Result: Effect not specified. Mellaril Tablets (Thioridazine Hydrochloride), p. 2269, P. Result: Effect not specified. Calan Tablets (Verapamil Hydrochloride), p. 2419, P, may interact with: Lanoxin Tablets (Digoxin), p. 1128, P. Result: Chronic verapamil treatment can increase serum digoxin levels and this can result in digitalis toxicity. Inderal Tablets (Propranolol Hydrochloride), p. 2728, P. Result: Additive negative effects on heart rate, AV conduction and/or cardiac contractility; additive hypotensive effect; decrease in propranolol clearance. Lasix Injection, Oral Solution and Tablets (Furosemide), p. 1240, P. Result: Additive effect on lowering blood pressure. Quinidex Extentabs (Quinidine Sulfate), p. 2067, P. Result: Hypotension in patients with hypertrophic cardiomyopathy; increased quinidine levels. *** End of Report *** This report is based solely on product labeling as published by PDR (R). Copyright (C) 1996 by Medical Economics Data Production Company, Montvale NJ. All rights reserved. ***************************************************************************